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Coaxing coagulation with RNA and cell fragments

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Two new therapeutic strategies show promise in mouse models of hemophilia. One uses an RNA repair approach relying on trans-splicing to patch a genetic defect in a mouse model. Another aims at microparticles, cell fragments that seem to promote coagulation (pages 1015–1019 and 1020–1025).

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Figure 1: The coagulation cascade.
Figure 2: RNA repair by spliceosome-mediated RNA trans-splicing.

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  1. Howard Hughes Medical Institute, Children's Hospital of Philadelphia, Abramson Bldg. 310, 3615 Civic Center Blvd, Philadelphia, 19104, Pennsylvania, USA

    Katherine A High

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  1. Katherine A High
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High, K. Coaxing coagulation with RNA and cell fragments. Nat Med 9, 991–992 (2003). https://doi.org/10.1038/nm0803-991

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