Drugs designed to protect or rescue neurons from damage wrought by stroke have repeatedly failed in clinical trials, prompting a mass flight of pharmaceutical companies from the field. A small Canadian startup is bucking the trend—and it hopes that monkey data will help the field evolve. Elie Dolgin reports.
This is a preview of subscription content, log in via an institution to check access.
References
World Health Organization. The 10 leading causes of death by broad income group http://www.who.int/mediacentre/factsheets/fs310/en/index.html (2008).
Lees, K.R. et al. N. Engl. J. Med. 354, 588–600 (2006).
Shuaib, A. et al. N. Engl. J. Med. 357, 562–571 (2007).
Sattler, R. et al. Science 284, 1845–1848 (1999).
Aarts, M. et al. Science 298, 846–850 (2002).
Sun, H.S. et al. Stroke 39, 2544–2553 (2008).
Stroke Therapy Academic Industry Roundtable (STAIR). Stroke 30, 2752–2758 (1999).
Fisher, M. et al. Stroke 40, 2244–2250 (2009).
Cook, D.J., Teves, L. & Tymianski, M. Nature 483, 213–217 (2012).
Bråtane B.T. et al. Stroke 42, 3265–3270 (2011).
Bach, A. et al. Proc. Natl. Acad. Sci. USA 109, 3317–3322 (2012).
Kawaguchi, A.T. et al. J. Pharmacol. Exp. Ther. 332, 429–436 (2010).
Umemura, K. et al. J. Nucl. Med. 46, 1931–1936 (2005).
Matsuura, S. et al. Brain Res. 1410, 122–131 (2011).
Furuichi, Y., Maeda, M., Matsuoka, N., Mutoh, S. & Yanagihara, T. Exp. Neurol. 204, 138–146 (2007).
Li, J. et al. Brain Res. 1334, 65–72 (2010).
Bahjat, F.R. et al. J. Cereb. Blood Flow Metab. 31, 1229–1242 (2011).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dolgin, E. To serve and neuroprotect. Nat Med 18, 1003–1006 (2012). https://doi.org/10.1038/nm0712-1003
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm0712-1003
- Springer Nature America, Inc.
This article is cited by
-
Molecular basis of the alternative recruitment of GABAA versus glycine receptors through gephyrin
Nature Communications (2014)
-
The Neuroprotective Efficacy of Cell-Penetrating Peptides TAT, Penetratin, Arg-9, and Pep-1 in Glutamic Acid, Kainic Acid, and In Vitro Ischemia Injury Models Using Primary Cortical Neuronal Cultures
Cellular and Molecular Neurobiology (2014)