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Pregnancy hormones boost beta cells via serotonin

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Pregnancy increases the demand for insulin by various tissues in the body, a condition that can lead to gestational diabetes. To shield against this condition, insulin-producing beta cells proliferate in a process now shown to involve the local production of serotonin in response to lactogenic hormones (pages 804–808).

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Figure 1: Insulin-producing beta cells expand during pregnancy through pathways involving lactogenic and serotonergic signaling.

Katie Vicari

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Correspondence to Anil Bhushan.

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Georgia, S., Bhushan, A. Pregnancy hormones boost beta cells via serotonin. Nat Med 16, 756–757 (2010). https://doi.org/10.1038/nm0710-756

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