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RAF translocations expand cancer targets

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Chromosomal translocations can promote cancers by eliciting the expression of fusion genes with oncogenic activity. The identification of translocations affecting RAF genes in prostate and gastric cancers and melanoma provides compelling evidence for the key role of RAF signaling in a subset of these cancers and suggests possible new avenues for personalized cancer therapy (pages 793–798).

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Figure 1: RAF fusion genes in prostate and gastric cancer and melanoma.

Katie Vicari

References

  1. Palanisamy, N. et al. Nat. Med. 16, 793–798 (2010).

    Article  CAS  Google Scholar 

  2. Khazak, V., Astsaturov, I., Serebriiskii, I.G. & Golemis, E.A. Expert Opin. Ther. Targets 11, 1587–1609 (2007).

    Article  CAS  Google Scholar 

  3. Wellbrock, C., Karasarides, M. & Marais, R. Nat. Rev. Mol. Cell Biol. 5, 875–885 (2004).

    Article  CAS  Google Scholar 

  4. Davies, H. et al. Nature 417, 949–954 (2002).

    Article  CAS  Google Scholar 

  5. Dankort, D. et al. Nat. Genet. 41, 544–552 (2009).

    Article  CAS  Google Scholar 

  6. Dankort, D. et al. Genes Dev. 21, 379–384 (2007).

    Article  CAS  Google Scholar 

  7. Chapman, P. et al. Eur. J. Cancer Suppl. 7, 5 (2009).

    Article  Google Scholar 

  8. Flaherty, K. et al. J. Clin. Oncol. 27, 15s (2009).

    Article  Google Scholar 

  9. Ciampi, R. et al. J. Clin. Invest. 115, 94–101 (2005).

    Article  CAS  Google Scholar 

  10. Jones, D.T. et al. Cancer Res. 68, 8673–8677 (2008).

    Article  CAS  Google Scholar 

  11. Jones, D.T. et al. Oncogene 28, 2119–2123 (2009).

    Article  CAS  Google Scholar 

  12. Tomlins, S.A. et al. Nature 448, 595–599 (2007).

    Article  CAS  Google Scholar 

  13. Tomlins, S.A. et al. Science 310, 644–688 (2005).

    Article  CAS  Google Scholar 

  14. Kolch, W., Heidecker, G., Lloyd, P. & Rapp, U.R. Nature 349, 426–428 (1991).

    Article  CAS  Google Scholar 

  15. MacConaill, L.E. et al. PLoS One 4, e7887 (2009).

    Article  Google Scholar 

  16. Jeong, J.H. et al. PLoS One 3, e3949 (2008).

    Article  Google Scholar 

  17. Solit, D.B. et al. Nature 439, 358–362 (2006).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Martin McMahon is Efim Guzik Distinguished Professor of Cancer Biology at the Helen Diller Family Comprehensive Cancer Center, University of California–San Francisco, California, USA.,

    Martin McMahon

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  1. Martin McMahon
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Correspondence to Martin McMahon.

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McMahon, M. RAF translocations expand cancer targets. Nat Med 16, 749–750 (2010). https://doi.org/10.1038/nm0710-749

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