Skip to main content

Advertisement

Log in

Regulatory RNA goes awry in Alzheimer's disease

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

An antisense RNA may contribute to Alzheimer's disease by upregulating β-secretase (pages 723–730).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: Dysregulation of BACE1 and Aβ production in Alzheimer's disease.

Katie Ris-Vicari

References

  1. Faghigi, M.A. et al. Nat. Med. 14, 723–730 (2008).

    Article  Google Scholar 

  2. Vassar, R. et al. Science 286, 735–741 (1999).

    Article  CAS  Google Scholar 

  3. Dahm, R. & Macchi, P. Biol. Cell 99, 649–661 (2007).

    Article  CAS  Google Scholar 

  4. Rossner, S., Sastre, M., Bourne, K. & Lichtenthaler, S.F. Prog. Neurobiol. 79, 95–111 (2006).

    Article  CAS  Google Scholar 

  5. Mowrer, K.R. & Wolfe, M.S. J. Biol. Chem. published online, doi:10.1074/jbc.M801322200 (15 May 2008).

  6. Wang, W.X. et al. J. Neurosci. 28, 1213–1223 (2008).

    Article  Google Scholar 

  7. Hebert, S.S. et al. Proc. Natl. Acad. Sci. USA 105, 6415–6420 (2008).

    Article  CAS  Google Scholar 

  8. Lammich, S., Schobel, S., Zimmer, A.K., Lichtenthaler, S.F. & Haass, C. EMBO Rep. 5, 620–625 (2004).

    Article  CAS  Google Scholar 

  9. He, X., Li, F., Chang, W.P. & Tang, J. J. Biol. Chem. 280, 11696–11703 (2005).

    Article  CAS  Google Scholar 

  10. Puglielli, L., Ellis, B.C., Saunders, A.J. & Kovacs, D.M. J. Biol. Chem. 278, 19777–19783 (2003).

    Article  CAS  Google Scholar 

  11. Ehehalt, R., Keller, P., Haass, C., Thiele, C. & Simons, K. J. Cell Biol. 160, 113–123 (2003).

    Article  CAS  Google Scholar 

  12. Capell, A. et al. J. Biol. Chem. 277, 5637–5643 (2002).

    Article  CAS  Google Scholar 

  13. Willem, M. et al. Science 314, 664–666 (2006).

    Article  CAS  Google Scholar 

  14. Johnston, J.A. et al. Biochem. Soc. Trans. 33, 1096–1100 (2005).

    Article  CAS  Google Scholar 

  15. Wen, Y. et al. Neuron 57, 680–690 (2008).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

St George-Hyslop, P., Haass, C. Regulatory RNA goes awry in Alzheimer's disease. Nat Med 14, 711–712 (2008). https://doi.org/10.1038/nm0708-711

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0708-711

  • Springer Nature America, Inc.

Navigation