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Turning skin into embryonic stem cells

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Introducing four genes into mouse skin fibroblasts reprograms these cells into embryonic stem cells. If similar techniques work in human cells, patient-specific stem cells for tissue engineering and cell-based therapies may be closer to reality.

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Figure 1: Hypothetical strategy for using iPS cells in cell-based therapies.

Katie Ris

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Authors and Affiliations

  1. Howard Y. Chang is in the Program in Epithelial Biology, Stanford University, Stanford, California 94305, USA howchang@stanford.edu,

    Howard Y Chang

  2. George Cotsarelis is in the Dept. of Dermatology, Kligman Laboratories, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. cotsarel@mail.med.upenn.edu,

    George Cotsarelis

Authors
  1. Howard Y Chang
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  2. George Cotsarelis
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The authors declare no competing financial interests.

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Chang, H., Cotsarelis, G. Turning skin into embryonic stem cells. Nat Med 13, 783–784 (2007). https://doi.org/10.1038/nm0707-783

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