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Teasing out the tangles

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Tau aggregates into insoluble tangles in the brains of individuals with Alzheimer disease. Recent work suggests that these tangles do not cause the cognitive decline that typifies the disease.

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Figure 1: Axonal transport proceeds along microtubule tracks (blue), covered by microtubule-associated proteins (MAPs) such as tau (tan), which are involved in correct spacing and stabilization of the tracks (lower panel).

Katie Ris

References

  1. Ramsden, M. et al. J. Neurosci. 25, 10637–10647 (2005).

    Article  CAS  Google Scholar 

  2. Santacruz, K. et al. Science 309, 476–481 (2005).

    Article  CAS  Google Scholar 

  3. Spires, T.L. et al. Am. J. Pathol. 168, 1598–1607 (2006).

    Article  CAS  Google Scholar 

  4. Caughey, B. & Lansbury, P.T. Annu. Rev. Neurosci. 26, 267–298 (2003).

    Article  CAS  Google Scholar 

  5. Gotz, J. et al. Int. J. Dev. Neurosci. 22, 453–465 (2004).

    Article  Google Scholar 

  6. McLean, C.A. et al. Ann. Neurol. 46, 860–866 (1999).

    Article  CAS  Google Scholar 

  7. Lesne, S. et al. Nature 440, 352–357 (2006).

    Article  CAS  Google Scholar 

  8. Kril, J.J. et al. Acta Neuropathol. (Berl.) 103, 370–376 (2002).

    Article  Google Scholar 

  9. Arrasate, M. et al. Nature 431, 805–810 (2004).

    Article  CAS  Google Scholar 

  10. Ebneth, A. et al. J. Cell Biol. 143, 777–794 (1998).

    Article  CAS  Google Scholar 

  11. Mandelkow, E.M. et al. J. Cell Biol. 167, 99–110 (2004).

    Article  CAS  Google Scholar 

  12. Terry, R.D. J. Neuropathol. Exp. Neurol. 55, 1023–1025 (1996).

    Article  CAS  Google Scholar 

  13. Praprotnik, D. et al. Acta Neuropathol. (Berl.) 91, 226–235 (1996).

    Article  CAS  Google Scholar 

  14. Gotz, J. et al. J. Neurochem. (in the press).

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Authors and Affiliations

  1. Zentrum für Molekulare Biologie Heidelberg (ZMBH), Heidelberg, Germany

    Stefan Kins & Konrad Beyreuther

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  1. Stefan Kins
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  2. Konrad Beyreuther
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Kins, S., Beyreuther, K. Teasing out the tangles. Nat Med 12, 764–765 (2006). https://doi.org/10.1038/nm0706-764

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