How do Aβ levels increase in individuals with Alzheimer disease? Recent work suggests that some forms of neuronal activity can drive Aβ accumulation in the brain.
References
Cirrito, J.R. et al. Neuron 48, 913–922 (2005).
Kamenetz, F. et al. Neuron 37, 925–937 (2003).
Lazarov, O., Lee, M., Peterson, D.A. & Sisodia, S.S. J. Neurosci. 22, 9785–9793 (2002).
Sheng, J.G., Price, D.L. & Koliatsos, V.E. J. Neurosci. 22, 9794–9749 (2002).
Buckner, R.L. et al. J. Neurosci. 25, 7709–7717 (2005).
Kim, D.Y., Ingano, L.A., Carey, B.W., Pettingell, W.H. & Kovacs, D.M. J. Biol. Chem. 280, 23251–23261 (2005).
Nitsch, R.M., Farber, S.A., Growdon, J.H. & Wurtman, R.J. Proc. Natl. Acad. Sci. USA 90, 5191–5193 (1993).
Selkoe, D.J. & Schenk, D. in Annual Review of Pharmacology and Toxicology Vol 43 (eds. Cho, A.K., Blaschke, T.F., Insel, P.A. & Loh, H.H.) 545–584 (Annual Reviews, Palo Alto, California, 2003).
Bateman, R. et al. Nat. Med. 12, 856–861 (2006).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Selkoe, D. The ups and downs of Aβ. Nat Med 12, 758–759 (2006). https://doi.org/10.1038/nm0706-758
Issue Date:
DOI: https://doi.org/10.1038/nm0706-758
- Springer Nature America, Inc.
This article is cited by
-
Effect of Phenolic Compounds Against Aβ Aggregation and Aβ-Induced Toxicity in Transgenic C. elegans
Neurochemical Research (2012)
-
Lipoxygenases and Poly(ADP-Ribose) Polymerase in Amyloid Beta Cytotoxicity
Neurochemical Research (2011)
-
The Pathogenic Implication of Abnormal Interaction Between Apolipoprotein E Isoforms, Amyloid-beta Peptides, and Sulfatides in Alzheimer’s Disease
Molecular Neurobiology (2010)
-
Mechanisms of amyloid plaque pathogenesis
Acta Neuropathologica (2007)
-
Alzheimer 100 – highlights in the history of Alzheimer research
Journal of Neural Transmission (2006)