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Wormless without wingless

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A mouse model of Joubert syndrome helps identify a crucial role for Wnt signaling in early cerebellar proliferation and midline fusion (pages 726–731). Reduced activity of this pathway causes cerebellar hypoplasia reminiscent of the cerebellar malformation observed in humans with Joubert syndrome.

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Figure 1: Jbn activity is required for Wnt-mediated proliferation at the dorsal midline of the embryonic cerebellum.

Katie Vicari

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Authors and Affiliations

  1. Dan Doherty and Kathleen J. Millen are in the Division of Genetic Medicine, Department of Pediatrics, University of Washington, Center for Integrative Brain Research, Seattle Children's Hospital, Seattle, Washington, USA.,

    Dan Doherty & Kathleen J Millen

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  1. Dan Doherty
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  2. Kathleen J Millen
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Correspondence to Dan Doherty.

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The authors declare no competing financial interests.

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Doherty, D., Millen, K. Wormless without wingless. Nat Med 17, 663–665 (2011). https://doi.org/10.1038/nm0611-663

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