The energy-regulating hormone leptin affects signals emerging from certain brain regions. New results explore the nature of these signals, finding a central role for phosphoinositide-3 kinase in the brain and the endocannabinoid system in adipocytes (pages 667–675).
References
Buettner, C. et al. Nat. Med. 14, 667–675 (2008).
Ahima, R.S. et al. Nature 382, 250–252 (1996).
Myers, M.G., Cowley, M.A. & Munzberg, H. Annu. Rev. Physiol. 70, 537–556 (2008).
Bjorbaek, C. & Kahn, B.B. Recent Prog. Horm. Res. 59, 305–331 (2004).
Guo, K. et al. Endocrinology 148, 3987–3997 (2007).
Halaas, J.L. et al. Proc. Natl. Acad. Sci. USA 94, 8878–8883 (1997).
Cone, R.D. et al. Int. J. Obes. Relat. Metab. Disord. 25 Suppl 5, S63–S67 (2001).
Bates, S.H. et al. Nature 421, 856–859 (2003).
Gong, L. et al. Endocrinology published online, doi:10.1210/en.2007-0945 (10 April 2008).
Hill, J.W. et al. J. Clin. Invest. 118, 1796–1805 (2008).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Maratos-Flier, E. The long reach of leptin. Nat Med 14, 604–606 (2008). https://doi.org/10.1038/nm0608-604
Issue Date:
DOI: https://doi.org/10.1038/nm0608-604
- Springer Nature America, Inc.
This article is cited by
-
Mitochondrial Uncoupling Protein-2 (UCP2) Mediates Leptin Protection Against MPP+ Toxicity in Neuronal Cells
Neurotoxicity Research (2010)