Skip to main content
SpringerLink
Log in

Heme moves to center stage in cerebral malaria

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

In a mouse model of cerebral malaria, free heme molecules can induce inflammation and permeabilization of the blood brain barrier, leading to death. The enzyme heme oxygenase-1 or its product carbon monoxide can decrease free heme levels, offering a new therapeutic approach to this deadly complication.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Heme and HO-1 in experimental cerebral malaria.

Kim Caesar

References

  1. Pamplona, A. et al. Nat. Med. 13, 703–710 (2007).

    Article  CAS  Google Scholar 

  2. Hunt, N.H. & Grau, G.E. Trends Immunol. 24, 491–499 (2003).

    Article  CAS  Google Scholar 

  3. Belnoue, E. et al. J. Immunol. 169, 6369–6375 (2002).

    Article  CAS  Google Scholar 

  4. Gramaglia, I. et al. Nat. Med. 12, 1417–1422 (2006).

    Article  CAS  Google Scholar 

  5. Kossodo, S. et al. Immunology 91, 536–540 (1997).

    Article  CAS  Google Scholar 

  6. Stocker, R. & Perrella, M.A. Circulation 114, 2178–2189 (2006).

    Article  CAS  Google Scholar 

  7. Abraham, N.G. et al. Proc. Natl. Acad. Sci. USA 92, 6798–6802 (1995).

    Article  CAS  Google Scholar 

  8. Clark, I.A., Awburn, M.M., Harper, C.G., Liomba, N.G. & Molyneux, M.E. Malar. J. [online] 2, 41 (2003).

    Article  Google Scholar 

  9. Hvidberg, V. et al. Blood 106, 2572–2579 (2005).

    Article  CAS  Google Scholar 

  10. Cunnington, A.J., Kendrick, S.F., Wamola, B., Lowe, B. & Newton, C.R. Am. J. Trop. Med. Hyg. 71, 43–47 (2004).

    Article  CAS  Google Scholar 

  11. Takeda, M. et al. Jpn. J. Infect. Dis. 58, 268–271 (2005).

    CAS  PubMed  Google Scholar 

  12. Gordeuk, V.R. et al. Blood 85, 3297–3301 (1995).

    CAS  PubMed  Google Scholar 

  13. Koury, M.J. & Ponka, P. Annu. Rev. Nutr. 24, 105–131 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Nicholas H. Hunt is at the Molecular Immunopathology Unit and Roland Stocker is at the Centre for Vascular Research; Bosch Institute and Discipline of Pathology, School of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia. nicholas.hunt@bosch.org.au,

    Nicholas H Hunt & Roland Stocker

  2. Bosch Institute and Discipline of Pathology, School of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia. nicholas.hunt@bosch.org.au,

    Nicholas H Hunt & Roland Stocker

Authors
  1. Nicholas H Hunt
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Roland Stocker
    View author publications

    You can also search for this author in PubMed Google Scholar

Ethics declarations

Competing interests

Personal financial interest in form of consultancy fee, and the possibility of future research support. The authors declare that they are bound by confidentiality agreements that prevent them from further disclosing their financial interests in this work.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hunt, N., Stocker, R. Heme moves to center stage in cerebral malaria. Nat Med 13, 667–669 (2007). https://doi.org/10.1038/nm0607-667

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0607-667

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation