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Gateway to the metabolic syndrome

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A high-fat diet can lead to insulin resistance and the development of the metabolic syndrome, a condition associated with diabetes, heart disease and other ailments. A G-protein-coupled receptor on the surface of insulin-secreting cells in the pancreas senses lipids and may promote the metabolic syndrome under high-fat conditions.

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Figure 1: GPR40 mediates acute and chronic effects of fatty acids on insulin secretion.

Katie Ris

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Authors and Affiliations

  1. Department of Clinical Biochemistry and Medicine, University of Cambridge, Cambridge, CB2 2QR, UK

    Gema Medina-Gomez & Antonio Vidal-Puig

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  1. Gema Medina-Gomez
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  2. Antonio Vidal-Puig
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Medina-Gomez, G., Vidal-Puig, A. Gateway to the metabolic syndrome. Nat Med 11, 602–603 (2005). https://doi.org/10.1038/nm0605-602

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