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Validating Stat3 in cancer therapy

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The transcription factor STAT3 is overactive in many tumors and has attracted attention as a drug target. But in vivo evidence suggesting that inhibiting STAT3 could counteract cancer has been incomplete. The picture in the whole animal now begins to clarify, and it bodes well for this approach (pages 623–629).

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Figure 1: Normal activation-inactivation cycle of STAT3 and potential errors in regulation in cancer.

Katie Ris

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  1. Rockefeller University, New York, 10021, New York, USA

    James E Darnell Jr

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  1. James E Darnell Jr
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Darnell, J. Validating Stat3 in cancer therapy. Nat Med 11, 595–596 (2005). https://doi.org/10.1038/nm0605-595

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