Skip to main content

Advertisement

Log in

The mathematician versus the malignancy

  • News Feature
  • Published:

From Nature Medicine

View current issue Submit your manuscript

Patients have long received cancer treatments at the maximum tolerated dose on a regular schedule. Could a more sophisticated approach save lives? Elie Dolgin meets one mathematical biologist whose theories are now being tested in the clinic to see if they can improve the efficacy of today's anticancer arsenal.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Chmielecki, J. et al. Sci. Transl. Med. 3, 90ra59 (2011).

    Article  CAS  Google Scholar 

  2. Foo, J., Chmielecki, J., Pao, W. & Michor, F. J. Thorac. Oncol. 7, 1583–1593 (2012).

    Article  CAS  Google Scholar 

  3. Norton, L. & Simon, R. Cancer Treat. Rep. 61, 1307–1317 (1977).

    CAS  PubMed  Google Scholar 

  4. Citron, M.L. et al. J. Clin. Oncol. 21, 1431–1439 (2003).

    Article  CAS  Google Scholar 

  5. Goldie, J.H. & Coldman, A.J. Cancer Treat. Rep. 63, 1727–1733 (1979).

    CAS  PubMed  Google Scholar 

  6. Bonadonna, G., Zambetti, M., Moliterni, A., Gianni, L. & Valagussa, P. J. Clin. Oncol. 22, 1614–1620 (2004).

    Article  CAS  Google Scholar 

  7. Gatenby, R.A., Silva, A.S., Gillies, R.J. & Frieden, B.R. Cancer Res. 69, 4894–4903 (2009).

    Article  CAS  Google Scholar 

  8. Silva, A.S. et al. Cancer Res. 72, 6362–6370 (2012).

    Article  CAS  Google Scholar 

  9. Foo, J., Drummond, M.W., Clarkson, B., Holyoake, T. & Michor, F. PLoS Comput. Biol. 5, e1000503 (2009).

    Article  Google Scholar 

  10. Leder, K. et al. Cell 156, 603–616 (2014).

    Article  CAS  Google Scholar 

  11. Verhaak, R.G. et al. Cancer Cell 17, 98–110 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Dolgin, E. The mathematician versus the malignancy. Nat Med 20, 460–463 (2014). https://doi.org/10.1038/nm0514-460

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0514-460

  • Springer Nature America, Inc.

Navigation