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Modeling hyperactivity: of mice and men

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Although attention deficit hyperactivity disorder (ADHD) is a highly heritable and common psychiatric disorder, few susceptibility genes have been identified. A new multidisciplinary genetic study in humans and mice reveals GIT1 (encoding G protein–coupled receptor kinase–interacting protein-1) as a previously undescribed ADHD susceptibility gene in humans and provides new insights into the underlying mechanisms of this condition (pages 566–572).

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Figure 1: Loss of GIT1 reduces inhibitory presynaptic inputs from parvalbumin-positive interneurons.

Marina Corral

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Authors and Affiliations

  1. Yong-Seok Lee and Alcino J. Silva are in the Departments of Neurobiology, Psychology and Psychiatry; at the Integrative Center for Learning and Memory; and at the Brain Research Institute, all at the University of California–Los Angeles, Los Angeles, California, USA.,

    Yong-Seok Lee & Alcino J Silva

  2. at the Integrative Center for Learning and Memory,

    Yong-Seok Lee & Alcino J Silva

Authors
  1. Yong-Seok Lee
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  2. Alcino J Silva
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Correspondence to Alcino J Silva.

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The authors declare no competing financial interests.

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Lee, YS., Silva, A. Modeling hyperactivity: of mice and men. Nat Med 17, 541–542 (2011). https://doi.org/10.1038/nm0511-541

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