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The enemy within: dormant retroviruses awaken

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Mammalian genomes harbor regulatory elements from ancient retroviral infections. These retroviral remnants are normally silenced by DNA methylation—but this can change. Reactivation of one such element triggers the expression of a nearby oncogene during the development of Hodgkin's lymphoma (571–579).

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Figure 1: Aberrant expression of CSF1R is driven by the LTR of an endogenous retrovirus in Hodgkin's lymphoma.

Kimberly Caesar

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Authors and Affiliations

  1. Michael E. Engel is in the Department of Pediatrics, the Department of Cancer Biology, the Monroe Carell Jr. Children's Hospital and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.,

    Michael E Engel

  2. Scott W. Hiebert is in the Department of Pediatrics and the Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.,

    Scott W Hiebert

Authors
  1. Michael E Engel
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  2. Scott W Hiebert
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Correspondence to Michael E Engel or Scott W Hiebert.

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The authors declare no competing financial interests.

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Engel, M., Hiebert, S. The enemy within: dormant retroviruses awaken. Nat Med 16, 517–518 (2010). https://doi.org/10.1038/nm0510-517

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