Inhibitors of specific signaling molecules may provide future treatments for acute lymphocytic leukemia.
References
Cortes, J.E. & Kantarjian, H.M. Acute lymphoblastic leukemia — a comprehensive review with emphasis on biology and therapy. Cancer 76, 2393–2417 (1995).
Ihle, J.N. Cytokine receptor signaling. Nature 377, 591–594 (1995).
Levitski, A. & Gazit, A. Tyrosine kinase inhibition: An approach to drug development. Science 267, 1782–1789 (1995).
Meydan, N. et al. Inhibition of acute lymphoblastic leukemia by a Jak-2 inhibitor. Nature 379, 645–648 (1996).
Dvir, A. et al. The inhibition of EGF-dependent proliferation of keratinocytes by tyrphostin tyrosine kinase blockers. J. Cell Biol. 113, 857–865 (1991).
Kaur, G. et al. Tyrphostin induced growth inhibition: Correlation with effect on p210 bcr-abl autokinase activity in K562 chronic myelogenous leukemia. Anticancer Drugs 5, 213–222 (1994).
Migone, T.S. et al. Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I. Science 269, 79–81 (1995).
Danial, N.N., Pernis, A. & Rothman, P.B. Jak-STAT signaling induced by the v-abl oncogene. Science 269, 1875–1877 (1995).
Karp, J.E. & Broder, S. New directions in molecular medicine. Cancer Res. 54, 653–665 (1994).
Gibbs, J.B., Oliff, A. & Kohl, N.E. Farnesyl-transferase inhibitors. Ras research yields a potential cancer therapeutic. Cell 77, 175–178 (1994).
James, G.L. et al. Benzodiazepine peptidomimetics: Potent inhibitors of Ras farnesylation in animal cells. Science 260, 1937–1942 (1993).
Jones, R.J. et al. Bryostatin 1, a unique biologic response modifier: Anti-leukemic activity in vitro. Blood 75, 1319–1323 (1990).
May, W.S. et al. Antineoplastic bryostatins are multipotential stimulators of human hematopoietic progenitor cells. Proc. Natl. Acad. Sci. USA 84, 8483–8487 (1987).
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Ito, T., May, W. Drug development train gathering steam. Nat Med 2, 403–404 (1996). https://doi.org/10.1038/nm0496-403
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DOI: https://doi.org/10.1038/nm0496-403
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