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Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells

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Figure 1: In vitro effects of conditioned medium.
Figure 2: In vivo effects of concentrated conditioned medium from MSCs exposed to hypoxia.

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Acknowledgements

This work was supported in part by US National Institutes of Health Grants HL 72010, HL73219, HL 58516, HL 35610 (to V.J.D.) and HL 5320, HL 63985 (J.S.I). M. Gnecchi was partially supported by a research award from the University of Pavia and IRCCS Policlinico San Matteo, Pavia, Italy.

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Author notes

  1. Luis G Melo

    Present address: Department of Physiology, Queen's University, Kingston, Ontario, K7L 3N6, Canada

Authors and Affiliations

  1. Department of Medicine, Duke University Medical Center, DUMC 3701, Durham, 27710, North Carolina, USA

    Massimiliano Gnecchi, Luis G Melo, Fulvio Morello, Hui Mu, Lunan Zhang, Richard E Pratt & Victor J Dzau

  2. Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, 02115, Massachusetts, USA

    Massimiliano Gnecchi, Huamei He, Olin D Liang, Luis G Melo, Fulvio Morello, Hui Mu, Nicolas Noiseux, Lunan Zhang, Richard E Pratt, Joanne S Ingwall & Victor J Dzau

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  1. Massimiliano Gnecchi
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Correspondence to Victor J Dzau.

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Gnecchi, M., He, H., Liang, O. et al. Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells. Nat Med 11, 367–368 (2005). https://doi.org/10.1038/nm0405-367

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