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Chromosomal translocation products engender new intracellular therapeutic technologies

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Chromosomal translocations occur in leukemias, lymphomas, sarcomas and some epithelial tumors and some generate unique fusion proteins. These translocation products may provide tumor-specific targets for the development of new therapeutic strategies tailored to a malignant cell.

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Figure 1: Consequences of chromosomal translocations in human tumors.
Figure 2: Intracellular therapy strategies for products of chromosomal translocations.
Figure 3: Mouse models of chromosomal translocation are essential for objective assessment of potential therapeutic reagents before clinical application.

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Authors and Affiliations

  1. MRC Laboratory of Molecular Biology, Cambridge, UK

    Terence H. Rabbitts & Martin R. Stocks

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  1. Terence H. Rabbitts
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  2. Martin R. Stocks
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Correspondence to Terence H. Rabbitts.

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Competing interests

T.H.R. is a consultant for Iclectus Ltd. M.R.S. is an employee of Iclectus Ltd.

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Rabbitts, T., Stocks, M. Chromosomal translocation products engender new intracellular therapeutic technologies. Nat Med 9, 383–386 (2003). https://doi.org/10.1038/nm0403-383

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