Skip to main content
Log in

IL-6 release and airway administration of human CFTR cDNA adenovirus vector

  • Letters to the Editor
  • Published:

From Nature Medicine

View current issue Submit your manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Rosenfeld, M.A. et al. In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium. Cell 68, 143–155 (1992).

    Article  CAS  Google Scholar 

  2. Crystal, R.G. et al. Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis. Nature Genet. 8, 42–51 (1994).

    Article  CAS  Google Scholar 

  3. Crystal, R.G. Protocol for gene therapy of the respiratory manifestations of cystic fibrosis using a replication deficient recombinant adenovirus to transfer the normal cystic fibrosis transmembrane conductance regulator cDNA to the airway epithelium. Fed. Register 58, 21737–21738 (1992).

    Google Scholar 

  4. Brody, S.L., Metzger, M., Danel, C., Rosenfeld, M. & Crystal, R.G. Acute responses of non-human primates to airway delivery of an adenovirus vector containing the human cystic fibrosis transmembrane conductance regulator cDNA. Hum. Gene Ther. 5, 821–836 (1994).

    Article  CAS  Google Scholar 

  5. Zabner, J. et al. Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis. Cell 75, 207–216 (1993).

    Article  CAS  Google Scholar 

  6. Wilson, J.M. Gene therapy of cystic fibrosis lung disease using El deleted adenovirus: a phase 1 trial. Fed. Register 58, 47906 (1993).

    Google Scholar 

  7. Boucher, R.C. & Knowles, M.R. Gene therapy for cystic fibrosis using El deleted adenovirus: a phase 1 trial in the nasal cavity. Fed. Register 58, 53814 (1993).

    Google Scholar 

  8. Wilmott, R.W., Whitsett, J. & Trapnell, B. A phase 1 study of gene therapy of cystic fibrosis utilizing a replication deficient recombinant adenovirus vector to deliver the human cystic fibrosis transmembrane conductance regulator cDNA to the airways. Fed. Register 58, 21739 (1993).

    Google Scholar 

  9. Van Snick, J., Interleukin-6: An overview. Annu. Rev. Immun. 8, 253–278 (1990).

    Article  CAS  Google Scholar 

  10. Weber, J. et al. Phase 1 trial of subcutaneous interleukin-6 in patients with advanced malignancies. J. clin. Oncol. 11, 499–506 (1993).

    Article  CAS  Google Scholar 

  11. McElvaney, N.G. et al. Modulation of airway inflammation in cystic fibrosis: in vivo suppression of interleukin-8 levels on the respiratory epithelial surface by aerosolization of recombinant secretory leukoprotease inhibitor. J. clin. Invest. 90, 1296–1301 (1992).

    Article  CAS  Google Scholar 

  12. Melani, C. et al. Interleukin-6 expression in human neutrophil and eosinophil periphera blood granulocytes. Blood 81, 2744–2749 (1993).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

McElvaney, N., Crystal, R. IL-6 release and airway administration of human CFTR cDNA adenovirus vector. Nat Med 1, 182–184 (1995). https://doi.org/10.1038/nm0395-182b

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0395-182b

  • Springer Nature America, Inc.

This article is cited by

Navigation