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Metabolism unhinged: IDH mutations in cancer

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Recently characterized IDH1 and IDH2 mutations in leukemia and glioblastoma have introduced a fascinating cancer-specific role for metabolic genes essential to cellular respiration. Studies also link aberrant IDH1 and IDH2 activity to an altered metabolite profile, an observation that may have broad implications for both cancer epigenetics and clinical management of disease.

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Figure 1: Mutant IDH1 and IDH2 activity and 2-HG signaling in cancer.

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Authors and Affiliations

  1. John R. Prensner is in the Department of Pathology and the Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA,

    John R Prensner

  2. Arul M. Chinnaiyan is in the Departments of Pathology and Urology and the Michigan Center for Translational Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA, and the Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.,

    Arul M Chinnaiyan

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  1. John R Prensner
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  2. Arul M Chinnaiyan
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Correspondence to Arul M Chinnaiyan.

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The authors declare no competing financial interests.

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Prensner, J., Chinnaiyan, A. Metabolism unhinged: IDH mutations in cancer. Nat Med 17, 291–293 (2011). https://doi.org/10.1038/nm0311-291

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