X-box–binding protein-1 (XBP-1) increases insulin sensitivity by activating endoplasmic reticulum capacity during feeding to control glucose homeostasis, a function severely impaired in obesity. But XBP-1 can also increase glucose tolerance in obese and diabetic mice by blocking gluconeogenesis, independent of its effect on insulin sensitivity, opening new avenues for type 2 diabetes therapies (pages 356–365).
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Katie Vicari
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Ueki, K., Kadowaki, T. The other sweet face of XBP-1. Nat Med 17, 246–248 (2011). https://doi.org/10.1038/nm0311-246
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DOI: https://doi.org/10.1038/nm0311-246
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