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Interleukin-22: a sheep in wolf's clothing

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Interleukin-22, a component of the immune system most studied for its role in autoimmunity, has a more beneficial side. Two studies show how this cytokine fights off microbes in the mucosa of the lung and gut (pages 275–281 and 282–289).

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Figure 1: IL-22 protects against extracellular bacterial pulmonary and enteric infections.

Katie Ris-Vicari

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Laurence, A., O'Shea, J. & Watford, W. Interleukin-22: a sheep in wolf's clothing. Nat Med 14, 247–249 (2008). https://doi.org/10.1038/nm0308-247

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