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Regulatory T-cell development: is Foxp3 the decider?

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Regulatory T cells (Tregs) have gone from obscurity to rock-star status in the past decade, prompting intense scrutiny—but what exactly are they? Four studies examine this question, delving deeply into the role of the transcription factor Foxp3 in governing Treg differentiation and function.

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Figure 1: Foxp3 and its control over regulatory T-cell development.

Katie Ris

References

  1. Bluestone, J.A. & Abbas, A.K. Nat. Rev. Immunol. 3, 253–257 (2003).

    Article  CAS  Google Scholar 

  2. Hori, S., Nomura, T. & Sakaguchi, S. Science 299, 1057–1061 (2003).

    Article  CAS  Google Scholar 

  3. Marson, A. et al. Nature 445, 931–935 (2007).

    Article  CAS  Google Scholar 

  4. Zheng, Y. et al. Nature 445, 936–940 (2007).

    Article  CAS  Google Scholar 

  5. Gavin, M.A. et al. Nature 445, 771–775 (2007).

    Article  CAS  Google Scholar 

  6. Wan, Y.Y. & Flavell, R.A. Nature 445, 766–770 (2007).

    Article  CAS  Google Scholar 

  7. Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. & Toda, M. J. Immunol. 155, 1151–1164 (1995).

    CAS  PubMed  Google Scholar 

  8. Rudensky, A.Y., Gavin, M. & Zheng, Y. Cell 126, 253–256 (2006).

    Article  CAS  Google Scholar 

  9. Li, B. et al. Immunol. Rev. 212, 99–113 (2006).

    Article  CAS  Google Scholar 

  10. Bacchetta, R. et al. J. Clin. Invest. 116, 1713–1722 (2006).

    Article  CAS  Google Scholar 

  11. Gavin, M.A. et al. Proc. Natl. Acad. Sci. USA 103, 6659–6664 (2006).

    Article  CAS  Google Scholar 

  12. Bettelli, E. et al. Nature 441, 235–238 (2006).

    Article  CAS  Google Scholar 

  13. Kobie, J.J. et al. J. Immunol. 177, 6780–6786 (2006).

    Article  CAS  Google Scholar 

  14. Pennington, D.J. et al. Nature 444, 1073–1077 (2006).

    Article  CAS  Google Scholar 

  15. Nutt, S.L., Heavey, B., Rolink, A.G. & Busslinger, M. Nature 401, 556–562 (1999).

    Article  CAS  Google Scholar 

  16. Barnett, B., Kryczek, I., Cheng, P., Zou, W. & Curiel, T.J. Am. J. Reprod. Immunol. 54, 369–377 (2005).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Tyler J. Curiel is the director of the San Antonio Cancer Institute and scientific director of the Cancer Therapy & Research Center, San Antonio, Texas, USA. curielt@uthscsa.edu,

    Tyler J Curiel

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  1. Tyler J Curiel
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Curiel, T. Regulatory T-cell development: is Foxp3 the decider?. Nat Med 13, 250–253 (2007). https://doi.org/10.1038/nm0307-250

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