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Multiple sclerosis: trapped in deadly glue

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Two forms of glial cells have distinct roles in the neuroinflammatory cascade of a mouse model of multiple sclerosis. These cells serve as key targets for therapeutic intervention (pages 328–334 and 335–339).

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Figure 1: Neuroinflammation in EAE requires multiple steps of CD4+ T cell activation in distinct CNS compartments.

Deborah Maizels

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Authors and Affiliations

  1. Department of Neurology, Department of General Neurology and Hertie-Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany

    Michael Platten

  2. Department of Neurology and Neurological Sciences, Beckman Center for Molecular Medicine and the Interdepartmental Program in Immunology, Stanford University, Stanford, California, USA

    Lawrence Steinman

Authors
  1. Michael Platten
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  2. Lawrence Steinman
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Platten, M., Steinman, L. Multiple sclerosis: trapped in deadly glue. Nat Med 11, 252–253 (2005). https://doi.org/10.1038/nm0305-252

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