Skip to main content

Advertisement

SpringerLink
Log in

Unconventional T-cell activation by IL-15 in rheumatoid arthritis

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

Synovial T cells from rheumatoid patients, when activated by IL-15, stimulate production of the proinflammatory cytokine, TNF-α (pages 189–195).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Elliott, M.J. et al. Randomised double blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis. Lancet 344, 1105–1110 (1994).

    Article  CAS  Google Scholar 

  2. Baumgartner, S. et al. Double-blind, placebo controlled trial of tumor necrosis factor receptor (p60) fusion protein (TNFR:Fc) in active rheumatoid arthritis (Abstr.). Arthritis Rheum. 39 (Suppl.), S74 (1996).

    Google Scholar 

  3. Zvaifler, N.J. & Firestein, G.S. Pannus and panno-cytes: Alternative models of joint destruction in rheumatoid arthritis. Arthritis Rheum. 37, 783–789 (1994).

    Article  CAS  Google Scholar 

  4. Mclnnes, I.B., Leung, B.P., Sturrock, R.D., Field, M. & Liew, F.Y. Interleukin-15 mediates T-Cell dependent regulation of tumor necrosis factor a production in rheumatoid arthritis. Nature Med. 3, 189–195 (1997).

    Article  Google Scholar 

  5. Tagaya, Y., Bamford, R.N., DeFillipis, A.P. & Waldmann, T.A. IL-15: A pleiotropic cytokine with diverse receptor signalling pathways whose expression is controlled at multiple levels. Immunity 4, 329–336 (1996).

    Article  CAS  Google Scholar 

  6. Kirman, I. & Nielsen, O.H. Increased numbers of interleukin-15 expressing Cells in active ulcerative colitis. Am. J. Gastroenterol. 91, 1789–1794 (1996).

    CAS  PubMed  Google Scholar 

  7. Albani, S. & Carson, D.A. A multistep molecular mimicry hypothesis for the pathogenesis of rheumatoid arthritis. Immunol. Today 17, 466–470 (1996).

    Article  CAS  Google Scholar 

  8. Kouskoff, V. et al. Organ-specific disease provoked by systemic autoimmunity. Cell 87, 811–822 (1996).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Sam and Rose Stein Institute for Research on Aging and Department of Medicine University of California at San Diego, 9500 Gilman Drive, La folia, California, 92093-0663, USA

    Dennis A. Carson

Authors
  1. Dennis A. Carson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Carson, D. Unconventional T-cell activation by IL-15 in rheumatoid arthritis. Nat Med 3, 148–149 (1997). https://doi.org/10.1038/nm0297-148

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0297-148

  • Springer Nature America, Inc.

Search

Navigation