Skip to main content
SpringerLink
Log in

Viagra: now mending hearts

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

Viagra operates by increasing the levels of cGMP in target cells. This same mechanism underlies a newly discovered action of the drug in mouse hearts: counteracting hypertrophy (pages 214–222).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Sildenafil, PKG-1 and hypertrophy.

Ann Thomson

References

  1. Takimoto, E. et al. Nat. Med. 11, 214–222 (2005).

    Article  CAS  Google Scholar 

  2. Frey, N., Katus, H.A., Olson, E.N. & Hill, J.A. Circulation 109, 1580–1589 (2004).

    Article  Google Scholar 

  3. Olson, E.N. & Schneider, M.D. Genes Dev. 17, 1937–1956 (2003).

    Article  CAS  Google Scholar 

  4. Shah, A.M. & MacCarthy, P.A. Pharmacol. Ther. 86, 49–86 (2000).

    Article  CAS  Google Scholar 

  5. Massion, P.B., Feron, O., Dessy, C. & Balligand, J.L. Circ. Res. 93, 388–398 (2003).

    Article  CAS  Google Scholar 

  6. Lincoln, T.M. Cyclic GMP: Biochemistry, Physiology and Pathophysioogy. (R.G. Landes Company, Austin, Texas, 1994).

    Google Scholar 

  7. Feil, R., Lohmann, S.M., de Jonge, H., Walter, U. & Hofmann, F. Circ. Res. 93, 907–916 (2003).

    Article  CAS  Google Scholar 

  8. Wegener, J.W. et al. Circ. Res. 90, 18–20 (2002).

    Article  CAS  Google Scholar 

  9. Fiedler, B. et al. Proc. Natl. Acad. Sci. USA 99, 11363–11368 (2002).

    Article  CAS  Google Scholar 

  10. Kishimoto, I., Rossi, K. & Garbers, D.L. Proc. Natl. Acad. Sci. USA 98, 2703–2706 (2001).

    Article  CAS  Google Scholar 

  11. Force, T., Michael, A., Kilter, H. & Haq, S. J. Card. Fail. 8 Suppl 6, S351–S358 (2002).

    Article  CAS  Google Scholar 

  12. Akhter, S.A. et al. Science 280, 574–577 (1998).

    Article  CAS  Google Scholar 

  13. Dorn, G.W. II & Brown, J.H. Trends Cardiovasc. Med. 9, 26–34 (1999).

    Article  CAS  Google Scholar 

  14. Wettschureck, N. et al. Nat. Med. 7, 1236–1240 (2001).

    Article  CAS  Google Scholar 

  15. Patrucco, E. et al. Cell 118, 375–387 (2004).

    Article  CAS  Google Scholar 

  16. Tang, K.M. et al. Nat. Med. 9, 1506–1512 (2003).

    Article  CAS  Google Scholar 

  17. Surks, H.K. et al. Science 286, 1583–1587 (1999).

    Article  CAS  Google Scholar 

  18. Schlossmann, J. et al. Nature 404, 197–201 (2000).

    Article  CAS  Google Scholar 

  19. Pilz, R.B. & Casteel, D.E. Circ. Res. 93, 1034–1046 (2003).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Molecular Cardiology Research Institute, Tufts–New England Medical Center, Boston, 02111, Massachusetts, USA

    Michael E Mendelsohn

Authors
  1. Michael E Mendelsohn
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mendelsohn, M. Viagra: now mending hearts. Nat Med 11, 115–116 (2005). https://doi.org/10.1038/nm0205-115

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0205-115

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation