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Mucosal gatekeepers: Selecting HIV viruses for early infection

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Mucosal cells are the principal portal of HIV-1 entry. A new study in this issue shows that upon contact with a X4 and R5 virus subtype mixture present in the inoculum, mucosal epithelial cells are themselves resistant to virus infection. Rather, they select the R5 virus subtype for transport across the cell, bringing the virus in contact with mucosal CD4+ T lymphocytes, which starts the chain of infection. (pages 150–156)

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Figure 1: Schematized events in early HIV-1 infection in the intestinal mucosa. Cell-free HIV-1 or infected cells (both containing R5 and X4 viruses) encounter a mucosal surface.

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  1. Entrée muqueuse du VIH et immunité muqueuse Departement de Biologie Cellulaire Institut Cochin de Génétique Moléculaire, Paris, France

    Morgane Bomsel & Violaine David

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  1. Morgane Bomsel
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  2. Violaine David
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Bomsel, M., David, V. Mucosal gatekeepers: Selecting HIV viruses for early infection. Nat Med 8, 114–116 (2002). https://doi.org/10.1038/nm0202-114

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