It is possible that growth hormone can offer therapeutic benefits for treating some forms of heart failure.
References
Saccà, L., Cittadini, A. & Fazio, S. Growth hormone and the heart. Endocr. Rev. 15, 555–573 (1994).
Duerr, R.L. et al. Insulin-like growth factor-I enhances ventricular hypertrophy and function during the onset of experimental cardiac failure. J. Clin. Invest. 95, 619–627 (1995).
Yang, R., Bunting, S., Gillett, N., Clark, R. & Jin, H. Growth hormone improves cardiac performance in experimental heart failure. Circulation 92, 262–267 (1995).
Flyvbjerg, A., Jørgensen, K.D., Marshall, S.M. & ørskov, H. Inhibitory effect of octreotide on growth hormone-induced IGF-I generation and organ growth in hypophysectomized rats. Am. J. Physiol. 260, E568–E574 (1991).
Timsit, J. et al. Effects of chronic growth hormone hypersecretion on intrinsic contractility, energet ics, isomyosin pattern, and myosin adenosine triphosphatase activity of rat left ventricle. J. Clin. Invest. 86, 507–515 (1990).
Jørgensen, J.O.L. et al. Beneficial effects of growth hormone treatment in GH-deficient adults. Lancet 1, 1221–1225 (1989).
Ito, H. et al. Insulin-like growth factor-I induces hypertrophy with enhanced expression of muscle specific genes in cultured rat cardiomyocytes. Circulations 87, 1715–1721 (1993).
Wåhlander, H., Isgaard, J., Jennische, E. & Friberg, P. Left ventricular insulin-like growth factor I increases in early renal hypertension. Hypertension 19, 25–32 (1992).
Donohue, T.J. et al. Induction of myocardial insulin-like growth factor-I gene expression in left ventricular hypertrophy. Circulation 89, 799–809 (1994).
Baker, J., Liu, J.-P., Robertson, E.J. & Efstratiadis, A. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 75, 73–82 (1993).
Rosén, T. & Bengtsson, B.-Å. Premature mortality due to cardiovascular disease in hypopituitarism. Lancet 336, 285–288 (1990).
Cuneo, R.C., Wilmshurst, P., Lowy, C., McGauley, G. & Sønksen, P.H. Cardiac failure responding to growth hormone. Lancet 1, 838–839 (1989)
Frustaci, A., Perrone, G.A., Gentiloni, N. & Russo, M.A. Reversible dilated cardiomyopathy due to growth hormone deficiency. Am. J. Clin. Pathol. 97, 503–511 (1992).
Pfeffer, M.A. et al. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. N. Engl. J. Med. 327, 669–677 (1992).
Lompre, A.M. et al. Myosin isoenzyme redistribution in chronic heart overload. Nature 282, 105–107 (1979).
Izumo, S., Nadal-Ginard, B. & Mahdavi, V. All members of the MHC multigene family respond to thyroid hormone in a highly tissue-specific manner. Science 231, 597–600 (1986).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Saccà, L., Fazio, S. Cardiac performance: Growth hormone enters the race. Nat Med 2, 29–31 (1996). https://doi.org/10.1038/nm0196-29
Issue Date:
DOI: https://doi.org/10.1038/nm0196-29
- Springer Nature America, Inc.