Could immunization against cocaine be a viable prophylaxis for cocaine addiction?
References
Committee to Study Medication Development and Research at the National Institute on Drug Abuse. Introduction in Development of Medications for the Treatment of Opiate and Cocaine Addictions: Issues for the Government and Private Sector. (eds Fulco, C.E., Liverman, C.T. & Earley, L.E.) 36–37 (National Academy Press, Washington, DC, 1995).
Carrera, M.R.A. et al. Suppression of psychoactive effects of cocaine by active immunization. Nature. 378, 727–730 (1995).
Christenson, J.G. Radioimmunoassay for Benzoyl Ecogonine. US Patent 4102979 (1975).
Leute, R.K. & Bolz, G., Nitrogen Derivates of Benzoyl Ecogonine. US Patent 3888866 (1975).
Mule, S.J., Jukofsky, D., Kogan, M., De Pace, A. & Verebey, K. Evaluation of the radioimmunoassay for benzoylecgonine (a cocaine metabolite) in human urine. Clin. Chem. 23, 796–801 (1977).
Landry, D.W., Zhao, K., Yang, G.X-.Q., Glickman, M. & Georgidis, T.M. Antibody-catalyzed degradation of cocaine. Science. 259, 1899–1901 (1993).
Bonese, K.F., Wainer, B.H., Fitch, F.W., Rothberg, R.M. & Schuster, C.R. Changes in heroin selfadministration by a rhesus monkey after morphine immunisation. Nature. 252, 20–27 (1974).
Carroll, F.I., Lewin, A.H., Boja, J.W. & Kuhar, M.J. (Substituted phenyl) tropan-2-carboxyIic acid ester analogues of cocaine. in Drug Design for Neuroscience. (ed. Kozikowski, A.P.) 149–166 (Raven, New York, 1993).
Ritz, M.C., Lamb, R.J., Goldberg, S.R. & Kuhar, M.J. Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science. 237, 1219–1221 (1987).
Giros, B. et al. Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter. Mol. Pharmacol. 42, 383–390 (1992).
Vandenbergh, D.J., Perisco, A.M. & Uhl, G.R. A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic tag I RFLPs. Mol. Brain Res. 15, 161–166 (1992).
Kityama, S. et al. Dopamine transporter sitedirected mutations differentially alter substrate transport and cocaine binding. Proc. Natl. Acad. Sci. USA. 89, 7782–7785 (1992).
Carroll, F.I., Lewin, A.H. & Biswas, J. Chemical approaches to the treatment of cocaine abuse. Pharm. News. 1, 11–17 (1994).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Slusher, B., Jackson, P. A shot in the arm for cocaine addiction. Nat Med 2, 26–27 (1996). https://doi.org/10.1038/nm0196-26
Issue Date:
DOI: https://doi.org/10.1038/nm0196-26
- Springer Nature America, Inc.