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The idiotypic network in autoimmunity: antibodies that bind antibodies that bind antibodies

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A new theory about the development of autoimmunity has emerged from a surprising and disparate set of observations. The elements include antibodies that recognize antibodies, and a peculiar structural relationship between a sense- and antisense-encoded protein (pages 72–79).

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Figure 1: Chain of antibodies.
Figure 2: Antisense peptides and the idiotypic network.

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Authors and Affiliations

  1. Department of Medicine 'B', Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, 52621, Israel

    Yehuda Shoenfeld

  2. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, 69978, Israel

    Yehuda Shoenfeld

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  1. Yehuda Shoenfeld
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Shoenfeld, Y. The idiotypic network in autoimmunity: antibodies that bind antibodies that bind antibodies. Nat Med 10, 17–18 (2004). https://doi.org/10.1038/nm0104-17

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