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References
Selkoe, D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81, 741–766 (2001).
Mullan, M. et al. A pathologic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of β-amyloid. Nature Genet. 1, 345–347 (1992).
Citron, M. et al. Mutation of the β-amyloid precursor protein in familial Alzheimer's disease. Nature 360, 372 (1992).
Yan, R. et al. Membrane-anchored aspartyl protease with Alzheimer's disease β-secretase activity. Nature 402, 533–537 (1999).
Vassar, R. et al. β-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286, 735–741 (1999).
Cai, H. et al. BACE1 is the major β-secretase for generation of Aβ peptides by neurons. Nature Neurosci. 4, 233–234 (2001).
Authier, I. et al. Endosomal proteolysis of internalized insulin at the C-terminal region of the β chain by cathepsin D. J. Biol. Chem. 277, 9437–9446 (2002).
Sinha, S. et al. Purification and cloning of amyloid precursor protein β-secretase from human brain. Nature 402, 537–540 (1999).
Naslund, J. et al. Correlation between elevated levels of amyloid β-peptide in the brain and cognitive decline. JAMA 283, 1571–1577 (2000).
Konishi, Y., Lindholm, K., Yang, L.B., Li, R. & Shen, Y. Molecular isolation of living cortical neurons from rapidly autopsied human elderly brains using DNA-linker magnetic purification system. Am. J. Pathol. 161, 1567–1576 (2002).
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Yang, LB., Lindholm, K., Yan, R. et al. Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease. Nat Med 9, 3–4 (2003). https://doi.org/10.1038/nm0103-3
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DOI: https://doi.org/10.1038/nm0103-3
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