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When the KChIPs are down

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Defects in the mechanisms responsible for maintaining the heart's rhythmic contractions can be fatal. The finding that a defect in a potassium-channel accessory protein can predispose mice to cardiac arrhythmia provides insights into the molecular basis of this group of diseases.

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Figure 1: Functional consequences of loss of KChIP2 in the mouse heart and explanation of the transmural gradient in Ito in the human heart.

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  1. Department of Internal Medicine University of Utah, Salt Lake city, Utah, USA

    Michael C. Sanguinetti

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  1. Michael C. Sanguinetti
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Sanguinetti, M. When the KChIPs are down. Nat Med 8, 18–19 (2002). https://doi.org/10.1038/nm0102-18

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