A new mouse model of Rett syndrome, in which MECP2 can be selectively biotinylated, allows for the investigation of cell-specific effects of Rett-causing mutations on gene expression, particularly in female mice.
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Horvath, P., Monteggia, L. Engineering MeCP2 to spy on its targets. Nat Med 23, 1120–1122 (2017). https://doi.org/10.1038/nm.4425
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DOI: https://doi.org/10.1038/nm.4425
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