Three recent studies in mice have identified a specific receptor, GFRAL, for the known anorectic peptide GDF15. The finding increases mechanistic understanding of its effect and paves the way for the development of novel anti-obesity therapeutics.
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Cimino, I., Coll, A. & Yeo, G. GDF15 and energy balance: homing in on a mechanism. Nat Med 23, 1119–1120 (2017). https://doi.org/10.1038/nm.4414
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DOI: https://doi.org/10.1038/nm.4414
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