Cancer-associated mutations in speckle-type POZ (pox virus and zinc-finger) protein confer neomorphic activity, altering its substrate affinities and its response to bromodomain and extraterminal inhibitors in prostate and endometrial cancer.
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Fennell, K., Dawson, M. SPOP tips the balance of BETs in cancer. Nat Med 23, 1014–1015 (2017). https://doi.org/10.1038/nm.4398
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DOI: https://doi.org/10.1038/nm.4398
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