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Opioids: keeping the good, eliminating the bad

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Two new studies show that mechanisms mediating the opioid side effects of tolerance, hyperalgesia and physical dependence are mediated spinally and can be dissociated from analgesia. These side effects can be selectively targeted by clinically available drugs without affecting their pain-relieving effects.

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Figure 1: Spinal and peripheral mediation of opioid side effects.

Marina Corral Spence/Springer Nature

References

  1. Volkow, N.D. & McLellan, A.T. N. Engl. J. Med. 374, 1253–1263 (2016).

    Article  CAS  Google Scholar 

  2. Wang, Y. et al. Nat. Med. 18, 385–387 (2012).

    Article  Google Scholar 

  3. Gutstein, H.B. & Trujillo, K.A. Brain Res. 626, 332–334 (1993).

    Article  CAS  Google Scholar 

  4. Burma, N.E.B. et al. Nat. Med. http://dx.doi.org/10.1038/nm.4281 (2017).

  5. Corder, G. et al. Nat. Med. http://dx.doi.org/10.1038/nm.4262 (2017).

  6. Wise, R.A. & Koob, G.F. Neuropsychopharmacology 39, 254–262 (2014).

    Article  Google Scholar 

  7. Lee, M., Silverman, S.M., Hansen, H., Patel, V.B. & Manchikanti, L. Pain Physician 14, 145–161 (2011).

    Google Scholar 

  8. Cahill, C.M., Walwyn, W., Taylor, A.M., Pradhan, A.A. & Evans, C.J. Trends Pharmacol. Sci. 37, 963–976 (2016).

    Article  CAS  Google Scholar 

  9. Roeckel, L.A., Le Coz, G.M., Gavériaux-Ruff, C. & Simonin, F. Neuroscience 338, 160–182 (2016).

    Article  CAS  Google Scholar 

  10. Drdla, R., Gassner, M., Gingl, E. & Sandkühler, J. Science 325, 207–210 (2009).

    Article  CAS  Google Scholar 

  11. Zhou, H.Y., Chen, S.R., Chen, H. & Pan, H.L. J. Neurosci. 30, 4460–4466 (2010).

    Article  CAS  Google Scholar 

  12. Kim, D.H., Fields, H.L. & Barbaro, N.M. Brain Res. 516, 37–40 (1990).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Stephanie Puig and Howard B. Gutstein are in the Department of Anesthesiology and Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.,

    Stephanie Puig & Howard B Gutstein

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  1. Stephanie Puig
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  2. Howard B Gutstein
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Correspondence to Howard B Gutstein.

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The authors declare no competing financial interests.

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Puig, S., Gutstein, H. Opioids: keeping the good, eliminating the bad. Nat Med 23, 272–273 (2017). https://doi.org/10.1038/nm.4277

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