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Caspase-2 and tau—a toxic partnership?

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Misfolded and hyperphosphorylated forms of the microtubule-associated protein tau are thought to be responsible for some degree of neurodegeneration. The demonstration of a novel toxic cleavage of tau by caspase-2 opens up new therapeutic avenues.

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Figure 1: Caspase-2 cleavage of tau.

Katie Vicari/Nature Publishing Group

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Authors and Affiliations

  1. Department of Pathology and Cell Biology, Carol M. Troy and Michael L. Shelanski are at the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York, USA.,

    Carol M Troy & Michael L Shelanski

  2. Carol M. Troy is also in the Department of Neurology.,

    Carol M Troy

Authors
  1. Carol M Troy
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  2. Michael L Shelanski
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Correspondence to Michael L Shelanski.

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The authors declare no competing financial interests.

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Troy, C., Shelanski, M. Caspase-2 and tau—a toxic partnership?. Nat Med 22, 1207–1208 (2016). https://doi.org/10.1038/nm.4227

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