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Neutrophils are not required for resolution of acute gouty arthritis in mice

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Figure 1: MSU crystals can form aggregates in mice markedly deficient in neutrophils.
Figure 2: The depletion of neutrophils with anti-Gr-1 antibodies diminishes MSU-crystal-induced paw edema in mice.

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Acknowledgements

L.L.R. acknowledges support from the Arthritis National Research Foundation (ANRF), the US National Institutes of Health (grant K99AI110645), the European Commission Marie Skłodowska-Curie Individual Fellowship (H2020-MSCA-IF-2014 656086) and the French 'Institut National de la Santé et de la Recherche Médicale' (INSERM); N.G. is the recipient of a fellowship from the French “Fondation pour la Recherche Médicale FRM” and the Philippe Foundation; P.S. is supported by a Max Kade Fellowship of the Max Kade Foundation and the Austrian Academy of Sciences and a Schroedinger Fellowship of the Austrian Science Fund (FWF) (J3399-B21); S.J.G. acknowledges support from the US National Institutes of Health (grants R01 AR067145, U19 AI104209, NS 080062), the Tobacco-Related Disease Research Program at the University of California and the Department of Pathology, Stanford University School of Medicine.

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Author notes

  1. Philipp Starkl

    Present address: Current address: CeMM, Research Center for Molecular Medicine of the Austrian Academy of Sciences, and Department of Medicine I, Research Laboratory of Infection Biology, Medical University of Vienna, Vienna, Austria.,

Authors and Affiliations

  1. Department of Pathology, Stanford University School of Medicine, Stanford, California, USA

    Laurent L Reber, Nicolas Gaudenzio, Philipp Starkl & Stephen J Galli

  2. Département d'Immunologie, Unité des Anticorps en Thérapie et Pathologie, Institut Pasteur, Paris, France

    Laurent L Reber

  3. Institut National de la Santé et de la Recherche Médicale, Paris, U1222, France

    Laurent L Reber

  4. Sean N. Parker Center for Allergy and Asthma Research, Stanford University School of Medicine, Stanford, California, USA

    Nicolas Gaudenzio & Stephen J Galli

  5. Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA

    Stephen J Galli

Authors
  1. Laurent L Reber
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  2. Nicolas Gaudenzio
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  3. Philipp Starkl
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  4. Stephen J Galli
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Contributions

L.L.R. and S.J.G conceived the project. L.L.R., N.G., P.S. and S.J.G. were involved in experimental design. L.L.R. performed most of the experiments, analyzed and compiled the data. N.G. and P.S. helped with experiments. All authors participated in writing or editing the paper.

Corresponding authors

Correspondence to Laurent L Reber or Stephen J Galli.

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The authors declare no competing financial interests.

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Reber, L., Gaudenzio, N., Starkl, P. et al. Neutrophils are not required for resolution of acute gouty arthritis in mice. Nat Med 22, 1382–1384 (2016). https://doi.org/10.1038/nm.4216

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