Two new studies show that high-resolution imaging can detect active tuberculosis (TB) in people otherwise diagnosed as healthy. Individuals with these signs of active infection with Mycobacterium tuberculosis (Mtb) were at an increased risk of developing clinical TB.
This is a preview of subscription content, log in via an institution to check access.
Katie Vicari/Nature Publishing Group
References
Zumla, A., Raviglione, M., Hafner, R. & von Reyn, C.F. N. Engl. J. Med. 368, 745–755 (2013).
Cox, H.S., Morrow, M. & Deutschmann, P.W. Br. Med. J. 336, 484–487 (2008).
Esmail, H. et al. Nat. Med. 22, 1090–1093 (2016).
Malherbe, S.T. et al. Nat. Med. 22, 1094–1100 (2016).
Barry, C.E. III et al. Nat. Rev. Microbiol. 7, 845–855 (2009).
Rustad, T.R. et al. Nucleic Acids Res. 41, 509–517 (2013).
Mukamolova, G.V., Turapov, O., Malkin, J., Woltmann, G. & Barer, M.R. Am. J. Respir. Crit. Care Med. 181, 174–180 (2010).
Manina, G., Dhar, N. & McKinney, J.D. Cell Host Microbe 17, 32–46 (2015).
Chengalroyen, M.D. et al. Am. J. Respir. Crit. Care Med. http://dx.doi.org/10.1164/rccm.201604-0769OC (2016).
Turapov, O. et al. Antimicrob. Agents Chemother. 60, 2476–2483 (2016).
Lin, P.L. et al. Nat. Med. 20, 75–79 (2014).
Tuberculosis Research Centre, Madras & National Tuberculosis Institute, Bangalore. Am. Rev. Respir. Dis. 134, 27–33 (1986).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Schnappinger, D., Ehrt, S. A broader spectrum of tuberculosis. Nat Med 22, 1076–1077 (2016). https://doi.org/10.1038/nm.4186
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm.4186
- Springer Nature America, Inc.