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Friendly fire: anti-cytokine antibodies elicited by microbes

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A recent study suggests that exposure to the mold Aspergillus induces the production of antibodies that neutralize interferon-γ (IFN-γ), which increases the risk of mycobacterial disease.

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Figure 1: Mechanisms underlying mycobacterial disease in patients with neutralizing antibodies to IFN-γ.

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Acknowledgements

This work was supported in part by the Intramural Research Program of the National Institute of Allergy and Infectious Disease, NIH.

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Authors and Affiliations

  1. Luigi D. Notarangelo is in the Division of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.,

    Luigi D Notarangelo

  2. Steven M. Holland is in the Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.,

    Steven M Holland

Authors
  1. Luigi D Notarangelo
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  2. Steven M Holland
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Correspondence to Luigi D Notarangelo or Steven M Holland.

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The authors declare no competing financial interests.

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Notarangelo, L., Holland, S. Friendly fire: anti-cytokine antibodies elicited by microbes. Nat Med 22, 973–975 (2016). https://doi.org/10.1038/nm.4175

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