Little is known about the regulatory mechanisms of antifungal host defense. Two complementary studies show that the E3 ubiquitin ligase CBLB targets dectin-1 and dectin-2 for degradation, and thus exerts a strong anti-inflammatory effect.
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Acknowledgements
M.G.N. was supported by an ERC Consolidator Grant (#310372) and a Spinoza Grant of the Netherlands Organization for Scientific Research (NWO). F.L.V. was supported by the ERA-Net for Research Programs on Rare Diseases, 'EURO-CMC'.
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van de Veerdonk, F., Netea, M. CBLB ubiquitin ligase: a major regulator of antifungal immunity. Nat Med 22, 834–835 (2016). https://doi.org/10.1038/nm.4160
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DOI: https://doi.org/10.1038/nm.4160
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