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Oxidation and mitochondrial origin of NET DNA in the pathogenesis of lupus

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A new study of the pathogenesis of systemic lupus erythematosus (SLE) highlights the importance of mitochondria and mitochondrial reactive oxygen species (ROS) in the generation of neutrophil extracellular traps (NETs) that have the enhanced potential to elicit interferon-induced gene expression.

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Figure 1: The characteristics of NET release from neutrophils of healthy individuals or people with SLE or CGD.

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Authors and Affiliations

  1. Sylviane Muller is in the Immunopathology and Therapeutic Chemistry Unit of the CNRS Institute for Molecular and Cellular Biology, Strasbourg, France. She is also affiliated with the Institute for Advanced Studies and the Laboratory of Excellence Medalis, Strasbourg University, Strasbourg, France.,

    Sylviane Muller

  2. Marko Radic is in the Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, USA.,

    Marko Radic

Authors
  1. Sylviane Muller
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  2. Marko Radic
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Correspondence to Sylviane Muller or Marko Radic.

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The authors declare no competing financial interests.

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Muller, S., Radic, M. Oxidation and mitochondrial origin of NET DNA in the pathogenesis of lupus. Nat Med 22, 126–127 (2016). https://doi.org/10.1038/nm.4044

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