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Remodeling the susceptibility to stress-induced depression

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Depression is mechanistically not well understood. A new study investigates the expression of chromatin-remodeling complexes in a mouse model for depression and describes an epigenetic pathway that may explain why some individuals are more susceptible to stress-induced depression than others.

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Figure 1: Molecular mechanisms increasing susceptibility to depression upon chronic stress.

Katie Vicari/Nature Publishing Group

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Authors and Affiliations

  1. Farahnaz Sananbenesi and Andre Fischer are in the Research Group for Epigenetics in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases (DZNE) Göttingen, Göttingen, Germany,

    Farahnaz Sananbenesi & Andre Fischer

  2. Andre Fischer is also in the Department of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.,

    Andre Fischer

Authors
  1. Farahnaz Sananbenesi
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  2. Andre Fischer
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Correspondence to Andre Fischer.

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The authors declare no competing financial interests.

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Sananbenesi, F., Fischer, A. Remodeling the susceptibility to stress-induced depression. Nat Med 21, 1125–1126 (2015). https://doi.org/10.1038/nm.3970

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