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Unpleasant memories: tissue-embedded T cell memory drives skin hypersensitivity

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Tissue-resident memory T cells (TRM cells) protect against recurrent or renewed infection in barrier tissues such as skin and mucosa. A new study sheds light on the clonal origin of TRM cells and demonstrates a crucial role for tissue-embedded T cell memory in contact hypersensitivity in skin.

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Figure 1: TRM and recirculating memory T cells are derived from the same precursors.

Kim Caesar/Nature Publishing Group

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Authors and Affiliations

  1. Thomas Gebhardt and Francis R. Carbone are in the Department of Microbiology and Immunology, The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.,

    Thomas Gebhardt & Francis R Carbone

Authors
  1. Thomas Gebhardt
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  2. Francis R Carbone
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Correspondence to Thomas Gebhardt.

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Gebhardt, T., Carbone, F. Unpleasant memories: tissue-embedded T cell memory drives skin hypersensitivity. Nat Med 21, 551–552 (2015). https://doi.org/10.1038/nm.3874

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