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A cross-talk network that facilitates tumor virotherapy

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To target and kill cancer cells, oncolytic viruses exploit signaling pathways that promote tumor growth. A new study shows that the cancer stromal fibroblast factor FGF2 is a crucial component of a tumor–TGF-β axis that renders cancer cells sensitive to virus infection.

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Figure 1: Stromal FGF2 sensitizes cancer to oncolytic virus (OV) infection.

Kim Caesar/Nature Publishing Group

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Authors and Affiliations

  1. Department of Neurosurgery, Agnieszka Bronisz and E. Antonio Chiocca are at the Harvey Cushing Neuro-Oncology Laboratories, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.,

    Agnieszka Bronisz & E Antonio Chiocca

Authors
  1. Agnieszka Bronisz
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  2. E Antonio Chiocca
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Correspondence to Agnieszka Bronisz.

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The authors declare no competing financial interests.

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Bronisz, A., Chiocca, E. A cross-talk network that facilitates tumor virotherapy. Nat Med 21, 426–427 (2015). https://doi.org/10.1038/nm.3857

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