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Metabolic-epigenetic coupling in osteoclast differentiation

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Osteoclasts are required for bone resorption. A new study in mice indicates that osteoclast differentiation is stabilized by DNA methylation at Irf8 (encoding interferon regulatory factor 8) mediated by DNA methyltransferase 3a (Dnmt3a), which suppresses Irf8 gene expression. The activity of Dnmt3 in osteoclasts requires elevated oxidative metabolism.

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Figure 1: The role of DNA methylation in osteoclast differentiation.

Marina Corral Spence/Nature Publishing Group

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Authors and Affiliations

  1. Lionel B. Ivashkiv is in the Arthritis and Tissue Degeneration Program, David Z. Rosensweig Center for Genomics Research, Hospital for Special Surgery, New York, New York, USA

    Lionel B Ivashkiv

  2. and in the Graduate Program in Immunology and Microbial Pathogenesis, Weill Cornell Graduate School of Medical Sciences, New York, New York, USA

    Lionel B Ivashkiv

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  1. Lionel B Ivashkiv
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Correspondence to Lionel B Ivashkiv.

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Ivashkiv, L. Metabolic-epigenetic coupling in osteoclast differentiation. Nat Med 21, 212–213 (2015). https://doi.org/10.1038/nm.3815

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