The growth factor thrombopoietin (TPO) drives platelet biogenesis by inducing megakaryocyte production. A new study in mice identifies a feedback mechanism by which clearance of aged, desialylated platelets stimulates TPO synthesis by hepatocytes.
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Kile, B. Aging platelets stimulate TPO production. Nat Med 21, 11–12 (2015). https://doi.org/10.1038/nm.3780
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DOI: https://doi.org/10.1038/nm.3780
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