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Antiangiogenic VEGF-A in peripheral artery disease

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Vascular endothelial growth factor A (VEGF-A) is a potent proangiogenic cytokine elevated in patients with peripheral artery disease (PAD). A new study links impaired vascular regrowth in PAD to increased expression of an antiangiogenic splice variant of VEGF-A.

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Figure 1: Patients with PAD have decreased blood flow in leg arteries resulting from atherosclerotic plaques.

Katie Vicari/Nature Publishing Group

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Authors and Affiliations

  1. Joshua M. Boucher and Victoria L. Bautch are in the Department of Biology and the Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.,

    Joshua M Boucher & Victoria L Bautch

  2. Victoria L. Bautch is also at the McAllister Heart Institute, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.,

    Victoria L Bautch

Authors
  1. Joshua M Boucher
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  2. Victoria L Bautch
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Correspondence to Victoria L Bautch.

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The authors declare no competing financial interests.

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Boucher, J., Bautch, V. Antiangiogenic VEGF-A in peripheral artery disease. Nat Med 20, 1383–1385 (2014). https://doi.org/10.1038/nm.3767

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