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Osteoclast progenitors promote bone vascularization and osteogenesis

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Preosteoclasts give rise to bone-resorbing osteoclasts, which are crucial for skeletal homeostasis. A study now shows that preosteoclasts also contribute to bone formation by releasing platelet-derived growth factor-BB, which promotes bone vascularization and osteogenesis.

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Figure 1: POCs are precursors of bone-degrading osteoclasts.

Katie Vicari/Nature Publishing Group

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Authors and Affiliations

  1. Anjali P. Kusumbe and Ralf H. Adams are at the Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, and in the Faculty of Medicine, University of Münster, Münster, Germany.,

    Anjali P. Kusumbe & Ralf H. Adams

Authors
  1. Anjali P. Kusumbe
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  2. Ralf H. Adams
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Correspondence to Ralf H. Adams.

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The authors declare no competing financial interests.

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Kusumbe, A., Adams, R. Osteoclast progenitors promote bone vascularization and osteogenesis. Nat Med 20, 1238–1240 (2014). https://doi.org/10.1038/nm.3747

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